PUBLICATIONS
The BIM Deletion Polymorphism Potentiates the Survival of Leukemia Stem and Progenitor Cells and Impairs Response to Targeted Therapies
Leukemia
Yu MG, Nah GSS, Krishnan V, Sulaimi FN, Ng KP, Bhatt S, Chuah C, Bergstrom DE, Ong ST
2024 Manuscript in Press
TP53 Mutation-Mediated Immune Evasion in Cancer: Mechanisms and Therapeutic Implications
Cancers
Wang CQ, Tan JYM, Chitkara N, Bhatt S.
2024 Sep 3;16(17):3069. doi: https://doi.org/10.3390/cancers16173069
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
Leukemia
Chaudhry S, Beckedorff F, Jasdanwala SS, Totiger TM, Affer M, Lawal AE, Montoya S, Tamiro F, Tonini O, Chirino A, Adams A, Sondhi AK, Noudali S, Cornista AM, Nicholls M, Afaghani J, Robayo P, Bilbao D, Nimer SD, Rodríguez JA, Bhatt S, Wang E, Taylor J.
2024 Jul 13. doi: 10.1038/s41375-024-02328-1.
Acquired multi-drug resistance in AML is caused by low apoptotic priming in relapsed myeloblasts
Blood Cancer Discovery
Olesinski, EA; Bhatia, KS; Wang, CQ; Pioso, MS; Lin, XX; Mamdouh, AM; Ng, SX; Sandhu, V; Jasdanwala, SS; Yilma, B; Bohl, S; Ryan, JA; Malani, D; Luskin, MR;, Kallioniemi, O; Porkka, K; Adamia, S; Chng, WJ; Osato, M; Weinstock, DM; Garcia, JS; Letai, Anthony; Bhatt, S
2024 Feb 19 DOI: 10.1158/2643-3230.BCD-24-0001
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy
Blood
Miller, PG; Sperling, AS; Mayerhofer C; McConkey, ME; Ellegast, JM; Da Silva, C; Cohen, DM, Wang, CQ; Sharda, A; Yan, N; Saha, S; Schluter, C; Schechter, I; Słabicki, M' Sandoval, B; Khan, J; Boettcher, S; Gibson, CJ; Scadden, DT; Stegmaier, K; Bhatt, S, Lindsley, RC; Ebert, BL
2023 Dec 14;142(24):2079-2091
DFNA5-mediated pyroptosis is a driver for venetoclax and azacytidine synergy in myeloid leukemia
Mahesh, AN, Lai, JXY, Tng, MJL, Lin, WL, Wan, JC, Yoon, JH, Chen, KW, Bhatt S
2023 Nov 18
Cytochrome P450
Encyclopedia of Toxicology (Fourth Edition)
Mahesh AN, Bhatia KS, Bhatt S.
2023 Nov 1; Vol. 3 Pg 449-456
Cell Cycle
Encyclopedia of Toxicology (Fourth Edition)
Mahesh AN, Bhatia KS, Bhatt S.
2023 Nov 1; Vol. 2 Pg 667-674
Apoptosis, necrosis, and other forms of cell death
Encyclopedia of Toxicology (Fourth Edition)
Mahesh AN, Lim NSE, Wong MH, Ray SD, Bhatt S.
2023 Nov 1; Vol. 1 Pg 749-759
CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response
Leukemia
Jutzi JS, Marneth AE, Jiménez-Santos MJ, Hem J, Guerra-Moreno A, Rolles B, Bhatt S, Myers SA, Carr SA, Hong Y, Pozdnyakova O, van Galen P, Al-Shahrour F, Nam AS, Mullally A.
2022 Dec;37(2):359-369.
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Cancer Cell
Bhatt S, Pioso MS, Olesinski EA, Yilma B, Ryan JA, Mashaka T, Leutz B, Adamia S, Zhu H, Kuang Y, Mogili A, Louissaint AJ, Bohl SR, Kim AS, Mehta AK, Sanghavi S, Wang Y, Morris E, Halilovic E, Paweletz CP, Weinstock DM, Garcia JS, Letai A.
2020 Dec 14;38(6):872-890.e6
Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re-induction chemotherapy.
American Journal of Hematology
Garcia JS*, Bhatt S*, Fell G, Sperling AS, Burgess M, Keshishian H, Yilma B, Brunner A, Neuberg D, Carr SA, Ebert BL, Ballen K, Stone RM, DeAngelo DJ, Medeiros BC, Letai A.
2020 Mar;95(3):245-250.
Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.
Blood
Sperling AS, Burgess M, Keshishian H, Gasser JA, Bhatt S, Jan M, Słabicki M, Sellar RS, Fink EC, Miller PG, Liddicoat BJ, Sievers QL, Sharma R, Adams DN, Olesinski EA, Fulciniti M, Udeshi ND, Kuhn E, Letai A, Munshi NC, Carr SA, Ebert BL.
2019 Jul 11;134(2):160-170.
Statins enhance efficacy of venetoclax in blood cancers.
Science Translational Medicine
Lee JS, Roberts A, Juarez D, Vo TT, Bhatt S, Herzog LO, Mallya S, Bellin RJ, Agarwal SK, Salem AH, Xu T, Jia J, Li L, Hanna JR, Davids MS, Fleischman AG, O'Brien S, Lam LT, Leverson JD, Letai A, Schatz JH, Fruman DA.
2018 Jun 13;10(445).
Inhibition of USP10 induces degradation of oncogenic FLT3.
Nature Chemical Biology
Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ.
2017 Dec;13(12):1207-1215.
Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.
Blood
Matthews JM, Bhatt S, Patricelli MP, Nomanbhoy TK, Jiang X, Natkunam Y, Gentles AJ, Martinez E, Zhu D, Chapman JR, Cortizas E, Shyam R, Chinichian S, Advani R, Tan L, Zhang J, Choi HG, Tibshirani R, Buhrlage SJ, Gratzinger D, Verdun R, Gray NS, Lossos IS.
2016 Jul 14;128(2):239-48.
Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma.
Proceedings of the National Academy of Sciences of the United States of America
Sarosiek KA, Cavallin LE, Bhatt S, Toomey NL, Natkunam Y, Blasini W, Gentles AJ, Ramos JC, Mesri EA, Lossos IS.
2010 Jul 20;107(29):13069-74.